Which ion is best to promote tissue healing when using iontophoresis for a lower extremity ulceration?

Using iontophoresis to promote tissue healing, particularly for lower extremity ulcerations, has a specific application of certain ions due to their biological effects and interactions with tissues. Zinc is a crucial mineral for tissue regeneration and repair processes, making it particularly effective in promoting healing in wounds and ulcerations. It plays a vital role in protein synthesis, cell proliferation, and the inflammatory response, all of which are important in the healing process.

When using iontophoresis, zinc can be delivered transdermally to the targeted area, enhancing local tissue repair mechanisms and accelerating the healing of the ulcer. Its use is supported by evidence that indicates a positive effect on wound healing due to its role in collagen synthesis and immune function.

In contrast, while acetate, magnesium, and lidocaine have their own therapeutic benefits, they do not have the same direct and established role in enhancing tissue repair processes as zinc. Acetate is often used for its potential in breaking down calcium deposits, magnesium is involved in various body functions but not specifically for enhancing wound healing, and lidocaine serves primarily as a local anesthetic without direct benefits for tissue regeneration. Thus, zinc is recognized as the most effective ion for promoting tissue healing in this context.